Notorious for killing off main characters, Grey's Anatomy releases a trailer signaling that Justin Chambers' character, Alex Karev, will make his last appearance next Thursday. Fans on Twitter are in an uproar with one saying, "I am not prepared emotionally for this." Another says, " On behalf of all the Grey's Anatomy fans, You have broken our hearts. We would love you forever Alex." See the trailer here from Entertainment Tonight, but for the full story, watch the episode next Thursday night, March 5th at 8pm.